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In addition to the copper-induced accumulation of lipoylated mitochondrial DLAT enzymes, there is also a loss of ironsulfur (Fe-S) cluster proteins, leading to proteotoxic stress [21,39,40,41]

Initial side effects such as mild nausea, constipation, or reduced appetite typically reappear during the first two to three weeks of restart

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For laboratory use, the vial is typically reconstituted with a suitable solvent such as bacteriostatic water